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BRIC은 생명과학분야 연구자들의 학술정보 교류에 적극적으로 참가하실 학술웨비나 발표연사를 모십니다.
학술웨비나 개최완료
Role of Whi3 protein aggregation behavior in cell-cycle regulation and cell polarity
Protein Aggregation Behavior Regulates Cyclin Transcript Localization and Cell-Cycle Control
Dev. Cell, Volume 25, Issue 6, 572-584, 13 June 2013. Available online 13 June 2013 | http://dx.doi.org/10.1016/j.devcel.2013.05.007
Whi3 is a G1/S regulator and known to inhibit G1 CDK activity. It was first described as a cell-size control gene in a set of cell division cycle mutants in Saccharomyces cerevisiae. Dysfunction or deletion of Whi3 leads to abnormal cell cycle control and morphogenesis. Whi3 contains two conserved and interesting domains: a RRM domain which binds a large set of mRNAs, and a polyQ tract, which promotes protein aggregation. Although it is evident that these functions of Whi3 are tightly linked to many cellular functions such as cell cycle control or cell polarization, the basis, precise mechanisms and the role of Whi3 remain unknown. This thesis addresses some of the questions about the roles of Whi3 in cell functionality. How is cell cycle progression controlled through Whi3? What are the functions of the RRM and polyQ tract in Whi3 for the timing variability in cell cycle? How do the transcripts bound to Whi3 localize and why is it important for cell cycle control or cell polarization? Are there any other cellular function that are modulated by Whi3? The studies presented in this thesis demonstrate an unprecedented role for stabilization of G1 cyclin mRNA through Whi3 aggregation, as well as clustering of G1 cyclin mRNA. We also reveal novel functions of Whi3 aggregation and RNA binding in cell polarization, especially in polarized cell growth, morphogenesis and actin polarization. In this thesis, many novel microscopic, biochemical and bioinformatical techniques are described using Ashbya gossypii, which is a multinucleated and filamentous fungus. Ashbya is a powerful system to study timing variability in cell cycle and cell polarization due to multiple nuclear division in a common cytoplasm and the frequent maintenance and establishment of cell polarity in a cell regardless of cell cycle. Overall, this thesis describes new and multiple roles of Whi3 for cell cycle control and cell polarization.
개최 완료
학술웨비나
일시
2024년 03월 28일 (목) 오후 02시
연사
김정섭(한국뇌연구원, DGIST)
학술웨비나
일시
2024년 03월 27일 (수) 오전 10시
연사
목예진(Johns Hopkins Bloomberg School of Public Health)
학술웨비나
일시
2024년 03월 25일 (월) 오전 11시
연사
서준배(Iowa State University)
학술웨비나
일시
2024년 03월 22일 (금) 오후 03시
연사
오정주(Delft University of Technology)
학술웨비나
일시
2024년 03월 20일 (수) 오후 03시
연사
이혜윤(German Cancer Research Center (DKFZ))
학술웨비나
일시
2024년 03월 20일 (수) 오전 11시
연사
안주성(고려대학교)
학술웨비나
일시
2024년 03월 14일 (목) 오후 03시
연사
유황찬(전북대학교 의과대학)
학술웨비나
일시
2024년 03월 13일 (수) 오후 02시
연사
김진수(한국원자력의학원, 과학기술연합대학원대학교 KIRAMS 캠퍼스(UST-KIRAMS))
일시
2024년 03월 13일 (수) 오전 10시
연사
권오만(한국생명공학연구원)
학술웨비나
일시
2024년 03월 07일 (목) 오전 11시
연사
윤진희(기초과학연구원)