한빛사 논문
Dongyoon Shin1 Sang Jin Rhee3,4 Daun Shin3,4 Eun-Jeong Joo5,6 Hee Yeon Jung3,7,8 Sungwon Roh9 Sang-Hyuk Lee10 Hyeyoung Kim11 Minji Bang10 Kyu Young Lee5,12 Se Hyun Kim3 Jihyeon Lee1 Yoseop Kim1 Injoon Yeo2 Yeongshin Kim13 Jaenyeon Kim1 Jun Soo Kwon3,4,8 Kyooseob Ha3,4,8 Yong Min Ahn3,4,8 Youngsoo Kim1,2
1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
2Institute of Medical and Biological Engineering Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
4Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
5Department of Neuropsychiatry, School of Medicine, Eulji University, Daejeon, Republic of Korea
6Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University, Seoul, Republic of Korea
7Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea
8Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea
9Department of Psychiatry, Hanyang University Hospital and Hanyang University College of Medicine, Seoul, Republic of Korea
10Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
11Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea
12Department of Psychiatry, Nowon Eulji University Hospital, Seoul, Republic of Korea
13Interdisciplinary Program of Bioengineering, Seoul National University College of Engineering, Seoul, Republic of Korea
Correspondence Youngsoo Kim, Yong Min Ahn
Dongyoon Shin and Sang Jin Rhee contributed equally to this work as co-first authors.
Abstract
Dear editor,
We report that integrating proteomic and clinical data enables objective differentiation between major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). These major psychiatric disorders are associated with mortality and life-long disability.1 However, objective discrimination of these disorders remains a formidable challenge. Thus, this study aimed to distinguish MDD, BD, and SCZ by integrating targeted/untargeted proteomic data obtained from liquid chromatography-mass spectrometry (LC-MS) and clinical data.
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