한빛사 논문
Jeongwoo Parka,b,1, Byullee Parkb,c,1, Tae Yeong Kimd, Sungjin Junga, Woo June Choie, Joongho Ahnb,c, Dong Hee Yoonf, Jeongho Kimf, Seungwan Jeonb,c, Donghyun Leeb,c, Uijung Yongb,c, Jinah Janga,b,c,g, Won Jong Kima,h, Hong Kyun Kimf,2, Unyong Jeongd,2, Hyung Ham Kima,b,c,i,2, and Chulhong Kima,b,c,g,i,2
aSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea; bMedical Device Innovation Center, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea; cDepartment of Creative IT Engineering, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea; dDepartment of Materials Science and Engineering, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea; eSchool of Electrical and Electronics Engineering, Chung-Ang University, 06974 Seoul, Republic of Korea; fDepartment of Ophthalmology, School of Medicine, Kyungpook National University, 41944 Daegu, Republic of Korea gDepartment of Mechanical Engineering, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea; hDepartment of Chemistry, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea; and iDepartment of Electrical Engineering, Pohang University of Science and Technology, 37673 Pohang, Republic of Korea
1J.P. and B.P. contributed equally to this work.
2To whom correspondence may be addressed.
Abstract
Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound transducers suffers from low signal-to-noise ratios, high complexity, and bulky form factors, significantly limiting its applications. Here, we demonstrate a quadruple fusion imaging system using a spherically focused transparent ultrasound transducer that enables seamless integration of ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging. As a first application, we comprehensively monitored multiparametric responses to chemical and suture injuries in rats’ eyes in vivo, such as corneal neovascularization, structural changes, cataracts, and inflammation. As a second application, we successfully performed multimodal imaging of tumors in vivo, visualizing melanomas without using labels and visualizing 4T1 mammary carcinomas using PEGylated gold nanorods. We strongly believe that the seamlessly integrated multimodal system can be used not only in ophthalmology and oncology but also in other healthcare applications with broad impact and interest.
transparent ultrasound transducer, optical imaging, ultrasound imaging, multimodal imaging
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