한빛사 논문
Choong Yeon Kim1,6, Min Jeong Ku2,6, Raza Qazi1,3, Hong Jae Nam1, Jong Woo Park2, Kum Seok Nam1, Shane Oh1, Inho Kang1, Jae-Hyung Jang4, Wha Young Kim5, Jeong-Hoon Kim2,* & Jae-Woong Jeong1,*
1School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
2Department of Physiology, Graduate School of Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
3Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA.
4Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea.
5Department of Physiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
6These authors contributed equally: Choong Yeon Kim, Min Jeong Ku.
*Corresponding author
Abstract
Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications.
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