한빛사 논문
Hyunwoo Joo1,2,*, Youngsik Lee1,2,*, Jaemin Kim1,2,*, Jeong-Suk Yoo3, Seungwon Yoo1,2, Sangyeon Kim1,2, Ashwini Kumar Arya4,5, Sangjun Kim6, Seung Hong Choi1,7, Nanshu Lu6,8,9, Han Sang Lee3, Sanghoek Kim4,5,10,†, Soon-Tae Lee3,† and Dae-Hyeong Kim1,2,11,†
1Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.
2School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
3Department of Neurology, Seoul National University Hospital, Seoul 03080, Republic of Korea.
4Department of Electronic Engineering, Kyung Hee University, Yongin-si 17104, Republic of Korea.
5Institute for Wearable Convergence Electronics, Kyung Hee University, Yongin-si 17104, Republic of Korea.
6Department of Mechanical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
7Department of Radiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
8Department of Aerospace Engineering and Engineering Mechanics, Center for Mechanics of Solids, Structures and Materials, University of Texas at Austin, Austin, TX 78712, USA.
9Department of Biomedical Engineering, Texas Materials Institute, University of Texas at Austin, Austin, TX 78712, USA.
10Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin-si 17104, Republic of Korea.
11Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.
†Corresponding author.
*These authors contributed equally to this work.
Abstract
Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.
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