한빛사 논문
Lip Ket Chin,∇ Taehwang Son,∇ Jae-Sang Hong, Ai-Qun Liu, Johan Skog, Cesar M. Castro, Ralph Weissleder, Hakho Lee,* and Hyungsoon Im*
*Corresponding Authors
Hyungsoon Im - Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States;
Hakho Lee - Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States;
Authors
Lip Ket Chin - Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States; School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798 Singapore;
Taehwang Son - Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States;
Jae-Sang Hong - Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States;
Ai-Qun Liu - School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore;
Johan Skog - Exosome Diagnostics, a Bio-techne brand, Waltham, Massachusetts 02451, United States
Cesar M. Castro - Center for Systems Biology and Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, United States
Ralph Weissleder - Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States; Department of Systems Biology, Harvard Medical School,
Boston, Massachusetts 02115, United States;
Author Contributions
∇L.K.C. and T.S. contributed equally to the manuscript.
Abstract
Extracellular vesicles (EVs), actively shed from a variety of neoplastic and host cells, are abundant in blood and carry molecular markers from parental cells. For these reasons, EVs have gained much interest as biomarkers of disease. Among a number of different analytical methods that have been developed, surface plasmon resonance (SPR) stands out as one of the ideal techniques given its sensitivity, robustness, and ability to miniaturize. In this Review, we compare different SPR platforms for EV analysis, including conventional SPR, nanoplasmonic sensors, surface-enhanced Raman spectroscopy, and plasmonic-enhanced fluorescence. We discuss different surface chemistries used to capture targeted EVs and molecularly profile their proteins and RNAs. We also highlight these plasmonic platforms’ clinical applications, including cancers, neurodegenerative diseases, and cardiovascular diseases. Finally, we discuss the future perspective of plasmonic sensing for EVs and their potentials for commercialization and clinical translation.
KEYWORDS:surface plasmon resonance, nanoplasmonics, surface-enhanced Raman spectroscopy, plasmon-enhanced fluorescence, extracellular vesicles, biosensing, diagnostics, biomarkers
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