한빛사 논문
이화여자대학교
Haidong Li,[a] Dayeh Kim,[a] Qichao Yao,[b] Haoying Ge,[b] Jeewon Chung,[a] Jiangli Fan,[b, c] Jingyun Wang,[d] Xiaojun Peng,*[b, c] and Juyoung Yoon*[a]
[a]Dr. H. Li, D. Kim, J. Chung, Prof. J. Yoon Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
[b]Dr. Q. Yao, H. Ge, Prof. J. Fan, Prof. X. Peng State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian 116024, China
[c]Prof. J. Fan, Prof. X. Peng Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo 315016, China.
[d]Prof. J. Wang School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian 116024, China
*Corresponding author
Abstract
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumorigenesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme‐reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image‐guided intraoperative surgeries with high signal‐to‐noise ratios. In this review, we mainly summarize the latest advancements in enzyme‐reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future.
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