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이동훈 (Dong Hoon Lee) 저자 이메일 보기
Harvard T.H. Chan School of Public Health
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Dietary Inflammatory and Insulinemic Potential and Risk of Type 2 Diabetes: Results From Three Prospective U.S. Cohort Studies
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To examine whether proinflammatory and hyperinsulinemic diets are associated with increased risk of type 2 diabetes.

We prospectively followed 74,767 women from the Nurses’ Health Study (1984–2016), 90,786 women from the Nurses’ Health Study II (1989–2017), and 39,442 men from the Health Professionals Follow-up Study (1986–2016). Using repeated measures of food-frequency questionnaires, we calculated empirical dietary inflammatory pattern (EDIP) and empirical dietary index for hyperinsulinemia (EDIH) scores, which are food-based indices that characterize dietary inflammatory or insulinemic potential based on circulating biomarkers of inflammation or C-peptide. Diagnoses of type 2 diabetes were confirmed by validated supplementary questionnaires.

We documented 19,666 incident type 2 diabetes cases over 4.9 million person-years of follow-up. In the pooled multivariable-adjusted analyses, individuals in the highest EDIP or EDIH quintile had 3.11 times (95% CI 2.96–3.27) and 3.40 times (95% CI 3.23–3.58) higher type 2 diabetes risk, respectively, compared with those in the lowest quintile. Additional adjustment for BMI attenuated the associations (hazard ratio 1.95 [95% CI 1.85–2.05] for EDIP and hazard ratio 1.87 [95% CI 1.78–1.98] for EDIH), suggesting adiposity partly mediates the observed associations. Moreover, individuals in both highest EDIP and EDIH quintiles had 2.34 times higher type 2 diabetes risk (95% CI 2.17–2.52), compared with those in both lowest quintiles, after adjustment for BMI.

Higher dietary inflammatory and insulinemic potential were associated with increased type 2 diabetes incidence. Findings suggest that inflammation and hyperinsulinemia are potential mechanisms linking dietary patterns and type 2 diabetes development.

- 형식: Research article
- 게재일: 2020년 09월 (BRIC 등록일 2020-09-14)
- 연구진: 국외연구진
- 분야: Medicine
Dot/Icm 제 4 유형 커플링 단백질 복합체의 선택적 이펙터 단백질 인식[Nat. Commun.]
발표: 김현민 (KAIST)
일자: 2020년 9월 29일 (화) 오후 02시 (한국시간)
언어: 한국어
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