한빛사 논문
Hee Ho Park1,†, Hong Nam Kim2,3,†, Hyelim Kim4,†, Youngbum Yoo5, Hyosoo Shin4,5, Eun Young Choi6,*, Jong-Sup Bae7,* and Wonhwa Lee5,7,*
1Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea.
2Center for BioMicrosystems, Brain Science Institute, Korea Instituteof Science and Technology (KIST), Seoul, 02792, Republic of Korea.
3Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.
4College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
5Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
6Department of Internal Medicine, Yeungnam University Medical Center, College of Medicine, Yeungnam University, Daegu 42415, South Korea.
7College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
†These authors contributed equally: Hee Ho Park, Hong Nam Kim, Hyelim Kim.
*Corresponding author
Abstract
The outbreak of highly contagious and deadly SARS-CoV-2, also known asCoronavirus Disease 2019 (COVID-19) has posed a serious threat to public healthacross the globe, calling for the development of effective diagnostic markersand therapeutics. Here, we report a highly reliable severity diagnosticbiomarker, acetylated 676th lysine transforming growth factor beta-inducedprotein (TGFBIp K676Ac). The TGFBIp K676Ac was consistently elevated in theblood of SARS-CoV-2 pneumonia patients (n=113); especially in patients ofintensive care unit (ICU) than non-ICU. Patients’ blood samples showedincreased cytokines and lymphopenia, which are exemplary evidences of SARS-CoV-2pneumonia. Treatment of TGFBIp neutralizing antibodies suppressed the cytokinestorm. The increased level of TGFBIp K676 Ac in ICU patients implies that it canbe used as a reliable severity diagnostic biomarker for SARS-CoV-2.
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