한빛사 논문
Sunho Park,†,⊥ Hyun-Ha Park,‡,⊥ Kahyun Sun,‡ Yonghyun Gwon,† Minho Seong,‡ Sujin Kim,† Tae-Eun Park,§ Hoon Hyun,¶ Yun-Hoon Choung,# Jangho Kim,*,† and Hoon Eui Jeong*,‡
†Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea
‡Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea
§School of Life Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea
¶Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea
#Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea
*Corresponding Authors
Author Contributions
⊥S.P. and H.-H.P. contributed equally to this work.
Abstract
Vertically aligned nanomaterials, such as nanowires and nanoneedles, hold strong potential as efficient platforms onto which living cells or tissues can be interfaced for use in advanced biomedical applications. However, their rigid mechanical properties and complex fabrication processes hinder their integration onto flexible, tissue-adaptable, and large-area patch-type scaffolds, limiting their practical applications. In this study, we present a highly flexible patch that possesses a spiky hydrogel nanostructure array as a transplantable platform for enhancing the growth and differentiation of stem cells and efficiently suppressing biofilm formation. In vitro studies show that the hydrogel nanospike patch imposes a strong physical stimulus to the membranes of stem cells and enhances their osteogenic, chondrogenic, and adipogenic differentiation and the secretion of crucial soluble factors without altering cell viability. At the same time, the array exhibits effective bactericidal properties against Gram-positive and Gram-negative bacteria. In vivo studies further demonstrate that the flexible hydrogel patch with its spiky vertical nanostructures significantly promotes the regeneration of damaged cranial bone tissues while suppressing pathogenic bacterial infections in mouse models.
KEYWORDS: antibacterial, differentiation, nanostructure, patch, stem cells
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