한빛사 논문
Jinhwan Kima, Donghyun Jangb, Hyeongmok Parkb, Sungjin Jungc, Dae Heon Kimd,* and Won Jong Kima,b,c,*
aCenter for Self-Assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Korea
bDepartment of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea
cSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea
dDepartment of Biology, Sunchon National University, Sunchon 57922, Korea
*To whom correspondence should be addressed.
Abstract
The discovery of sequence‐specific hybridization has allowed the development of DNA nanotechnology, which is divided into two categories: 1) structural DNA nanotechnology, which utilizes DNA as a biopolymer; and 2) dynamic DNA nanotechnology, which focuses on the catalytic reactions or displacement of DNA structures. Recently, numerous attempts have been made to combine DNA nanotechnologies with functional DNAs such as aptamers, DNAzymes, amplified DNA, polymer‐conjugated DNA, and DNA loaded on functional nanoparticles for various applications; thus, the new interdisciplinary research field of “functional DNA nanotechnology” is initiated. In particular, a fine‐tuned nanostructure composed of functional DNAs has shown immense potential as a programmable nanomachine by controlling DNA dynamics triggered by specific environments. Moreover, the programmability and predictability of functional DNA have enabled the use of DNA nanostructures as nanomedicines for various biomedical applications, such as cargo delivery and molecular drugs via stimuli‐mediated dynamic structural changes of functional DNAs. Here, the concepts and recent case studies of functional DNA nanotechnology and nanostructures in nanomedicine are reviewed, and future prospects of functional DNA for nanomedicine are indicated.
Keywords : cargo delivery, DNA nanotechnology, functional DNA, nanomedicine, self-assembly
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