한빛사 논문
Hee Jin Park, a,b,e,1 Dongwon Baek, b,1 Joon-Yung Cha, b Xueji Liao, b Sang-Ho Kang, c C. Robertson McClung, d Sang Yeol Lee, b Dae-Jin Yun, e,2 and Woe-Yeon Kim b,2
a Institute of Glocal Disease Control, Konkuk University, Seoul 05029, Republic of Korea
b Division of Applied Life Science (BK21Plus), Plant Molecular Biology and Biotechnology Research Center, Research Institute of Life Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea
c International Technology Cooperation Center, Rural Development Administration, Jeonju, 54875, Republic of Korea
d Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755
e Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Republic of Korea
1 These authors share senior authorship.
2 Correspondence : Woe-Yeon Kim, Dae-Jin Yun
Abstract
In plants, seasonal inputs such as photoperiod and temperature modulate the plant’s internal genetic program to regulate the timing of the developmental transition from vegetative to reproductive growth. This regulation of the floral transition involves chromatin remodeling, including covalent modification of histones. Here, we report that HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 15 (HOS15), a WD40 repeat protein, associates with a histone deacetylase complex to repress transcription of the GIGANTEA (GI)-mediated photoperiodic flowering pathway in Arabidopsis (Arabidopsis thaliana). Loss of function of HOS15 confers early flowering under long-day conditions because elevated GI expression. LUX ARRHYTHMO (LUX), a DNA binding transcription factor and component of the Evening Complex (EC), is important for the binding of HOS15 to the GI promoter. In wild type, HOS15 associates with the EC components LUX, EARLY FLOWERING 3 (ELF3), and ELF4 and the histone deacetylase HDA9 at the GI promoter, resulting in histone deacetylation and reduced GI expression. In the hos15-2 mutant, the levels of histone acetylation are elevated at the GI promoter, resulting in increased GI expression. Our data suggest that the HOS15–EC–HDA9 histone-modifying complex regulates photoperiodic flowering via the transcriptional repression of GI.
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