한빛사 논문
성균관대학교, 기초과학연구원
Sung Hyuk Sunwooa,b, Ju Seung Leec, SungJun Baea,b, Yiel Jae Shinc, Chang Seong Kimd, Soo Yeon Jood,e, Hong Sang Choid, Minah Suha,b, Soo Wan Kimd, Young Jin Choie,1, and Tae-il Kimb,c,1
aCenter for Neuroscience Imaging Research, Institute of Basic Science, 16419 Suwon, Korea; bDepartment of Biomedical Engineering, Sungkyunkwan University (SKKU), 16419 Suwon, Korea; cSchool of Chemical Engineering, Sungkyunkwan University (SKKU), 16419 Suwon, Korea; dDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, Korea; and eDepartment of Nanotechnology and Advanced Materials Engineering, Sejong University, 05006 Seoul, Korea
1To whom correspondence may be addressed.
Abstract
We present electrophysiological (EP) signals correlated with cellular cell activities in the adrenal cortex and medulla using an adrenal gland implantable flexible EP probe. With such a probe, we could observe the EP signals from the adrenal cortex and medulla in response to various stress stimuli, such as enhanced hormone activity with adrenocorticotropic hormone, a biomarker for chronic stress response, and an actual stress environment, like a forced swimming test. This technique could be useful to continuously monitor the elevation of cortisol level, a useful indicator of chronic stress that potentially causes various diseases.
biosensor, cortisol, electrophysiology, bioimplant, stress
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