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[APExBIO한국공식대리점] p-Cresyl sulfate Cas No.3233-58-7
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Catalog No. A8895
Protein-bound uremic retention solute
The p-Cresol is a protein-bound uremic retention solute 1.
Free p-Cresol was found to be a cardiovascular risk factor in non-diabetic hemodialysis patients. In patients with diabetes, the level of both free p-cresol and total p-cresol were markedly higher. In patients treated by hemodialysis, the levels of these two forms of p-cresol were also significantly higher than that of patients treated by hemodiafiltration. The univariate cox proportional hazard analysis showed that the concentration of free p-cresol was obviously associated with cardiovascular disease (CVD). Quite many patients with high free p-cresol concentrations had new fatal or non-fatal cardiovascular events. Besides that, p-cresol was also found to inhibit cell proliferation. It inhibited the proliferation of cultured endothelial cells by 26% without affecting cell viability. Moreover, p-cresol treatment reduced endothelial wound repair by 19%, 28% and 40% at concentrations of 10, 25 and 50 μg/ml, respectively 1,2.
References:
1. Meijers B K I, Bammens B, De Moor B, et al. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney international, 2008, 73(10): 1174-1180.
2. Dou L, Bertrand E, Cerini C, et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney international, 2004, 65(2): 442-451.
Physical Appearance | A solid |
Storage | Store at -20°C The product is not stable in solution, please dissolve it immediately before use. |
M.Wt | 188.20 |
Cas No. | 3233-58-7 |
Formula | C7H8O4S |
Solubility | ≥30.1mg/mL in DMSO, ≥50mg/mL in H2O |
Chemical Name | p-tolyl hydrogen sulfate |
Canonical SMILES | CC1=CC=C(OS(O)(=O)=O)C=C1 |
Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
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