연구용제품시약 > Chemical Reagent
[MedChemExpress한국독점대리점]Cibinetide
바이오클론
Signaling Pathway에 관련된 Biological Inhibitors
와 Biochemical Reagent 제조, 공급하는 회사
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Cibinetide
제품 설명
Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin/CD131 heteroreceptor, and used for neurological disease treatment.
In Vitro
Cibinetide (ARA290) enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs)[1]. Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
After ECFC transplantation to mice with CLI, a single Cibinetide (ARA290) injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4 h after transplantation[1]. Cibinetide (ARA290; 30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats[2]. Low-dosage Cibinetide (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
분자량
1257.31
화학식
C₅₁H₈₄N₁₆O₂₁
CAS No.
1208243-50-8
Sequence Shortening
{Glp}-EQLERALNSS
선적
Room temperature in continental US; may vary elsewhere.
보관
Powder | -80°C | 2 years |
---|---|---|
-20°C | 1 year | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
용액&용해도
In Vitro:
DMSO : ≥ 34 mg/mL (27.04 mM)
*"≥" means soluble, but saturation unknown.
Preparing
Stock Solutions
ConcentrationSolventMass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 0.7953 mL | 3.9767 mL | 7.9535 mL |
5 mM | 0.1591 mL | 0.7953 mL | 1.5907 mL |
10 mM | 0.0795 mL | 0.3977 mL | 0.7953 mL |
*Please refer to the solubility information to select the appropriate solvent.
References
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