연구용제품시약 > Chemical Reagent
[바이오클론] [MedChemExpress한국독점대리점]BSJ-04-132
바이오클론
Signaling Pathway에 관련된 Biological Inhibitors와 Biochemical Reagent 제조, 공급하는 회사인 MedChemExpress(MCE)를 소개합니다.(USA)
www.medchemexpress.com/
한국 독점대리점:바이오클론 ( www.bioclone.co.kr )
바이오클론(주)는 MedChem Express(MCE)의 한국공식독점대리점이며, 2015년부터 정부의 화학물질의 등록 및 평가 등에 관한 법률(화평법)에 의해 모든 화학물질을 한국환경공단에 신고, 허가 하에 안전하게 수입 공급하고 있습니다.
BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity.
제품 설명 |
BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1]. |
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IC50 & Target[1] |
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In Vitro
BSJ-04-132 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3[1].
Western Blot Analysis[1]
Cell Line: | Wildtype (WT) or Crbn-/- Jurkat cells |
Concentration: | 0.1, 0.5, 1, 5 μM |
Incubation Time: | For 4 hours |
Result: | Only resulted in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3. |
분자량
819.91
화학식
C₄₂H₄₉N₁₁O₇
CAS No.
2349356-39-2
SMILES
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCCCNC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C
선적
Room temperature in continental US; may vary elsewhere.
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
References
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