www.biorbyt.com
www.bioclone.co.kr/biorbyt
바이오클론은 영국 Biorbyt의 한국 독점 대리점
으로 합리적인 가격으로 제공하고 있습니다.
** Product Type **
§Antibodies §Small Molecules
§ELISA Kits §Biology Tools
§Proteins §Services
** Research Area **
§Neuroscience §Cacer §Cardiavascular
바이오클론㈜는 Biorbyt의 한국독점대리점이며, 2015년부터 정부의 화학물질 등록 및 평가 등에 관한 법률(화평법)에 의해 모든 화학물질을 한국환경공단에 신고, 허가하에 안전하게 수입, 공급하고 있습니다.
Alzheimers-pathway
•Alzheimer's disease (AD) is a debilitating neurodegenerative disorder. It is characterised by plaques made up of deposits between brain cells. These plaques are composed of a molecule called amyloid which leads to the formation of tangled twisted fibres made from tau, which is found within brain cells. This causes the death of brain cells, which is thought to bring about the symptoms of memory loss and dementia. •The processing of the integral membrane protein APP (Amyloid Precursor Protein) is fundamental to the progression of this disease. APP is initially cleaved by α-secretase to generate sAPP and a C83 carboxy-terminal fragment. The presence of sAPP is associated with normal synaptic signalling and results in synaptic plasticity, learning and memory, emotional behaviours, and neuronal survival. In the disease state, APP is cleaved sequentially by β-secretase and γ-secretase to release an extracellular fragment called A40-42. Aggregation of this fragment results in A40-42 oligomerization and plaque formation causing neurotoxicity, resulting in blocked ion channels, disruption of calcium homeostasis, mitochondrial oxidative stress, impaired energy metabolism, abnormal glucose regulation, and ultimately neuronal cell death. CDK5 and other kinases such as GSK3, PKC, PKA, and Erk2 are also activated by reactive oxygen species generated in the cell. This leads to hyperphosphorylation of Tau resulting in the dissociation of Tau from the microtubule, leading to microtubule destabilization and oligomerization of the Tau protein within the cell. Neurofibrillary tangles form because of Tau oligomerization and lead to apoptosis of the neuron.
Cat. No.
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Description
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Product Type
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orb11453
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Tau antibody
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Antibody
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orb181646
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BPTF antibody
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Antibody
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orb216018
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APP antibody
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Antibody
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orb69429
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Apolipoprotein E antibody
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Antibody
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orb405849
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Human Tau ELISA Kit
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ELISA Kit
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orb385274
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Human Apolipoprotein E ELISA Kit
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ELISA Kit
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orb414197
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Mouse alpha synuclein protein
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Protein
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orb86005
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Beta Amyloid (1-28) protein
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Peptide
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orb320986
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Amyloid- (25-35)
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Small Molecule
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orb181230
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DAPT
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Small Molecule
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small size와 Bulk size의 공급이 가능, 자세한 문의사항은 바이오클론으로 문의해 주시기 바랍니다.
궁금한 사항은 바이오클론으로 문의해 주세요.
Homepage : www.bioclone.co.kr
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