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[바이오클론] [Biorbyt 한국독점대리점] VEGF Signaling Pathway
제품(기술)분류: 시약 > Antibody
전화: 02-2690-0058
메일: bioclone(at).bioclone.co.kr
팩스: 02-2690-0397

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바이오클론Birobyt한국 독점 대리점으로
합리적인 가격으로 제공하고 있습니다.
** Product Type **

Antibodies (181,605) Small Molecules (24,617)

ELISA Kits (4,376) Biology Tools (52,433)

Proteins (17,660) Services (2)

** Research Area **

Neuroscience & Cancer & Cardiavascular



바이오클론㈜는 Biorbyt의 한국독점대리점이며, 2015년부터 정부의 화학물질 등록 및 평가 등에 관한 법률(화평법)에 의해 모든 화학물질을 한국환경공단에 신고, 허가하에 안전하게 수입, 공급하고 있습니다.

VEGF Signaling Pathway
 

VEGF pathway  활성화는 암에서자가 면역, 망막 병증에 이르기까지 다양한 질병 과정에서 확인되었습니다. VEGF ligand (bevacizumab, VEGF-Trap, ranibizumab)뿐만 아니라 VEGF receptor (cediranib, pazopanib, sorafenib, sunitinib, vandetanib, axitinib, telatinib, semaxanib, otesanib, vatalanib, Zactima)highly specific inhibitors 개발은 VEGF pathway 질병발생에 중심적인 역할을 한다는것에 의미를 둡니다 :)
 

Catalogue code

Description

Product Type

orb11557

VEGFR2

Antibody

orb76050

Human VEGFR2

ELISA Kit

orb437591

Porcine VEGFR2

ELISA Kit

orb244321

Human VEGFR2

Protein

orb191500

VEGF

Antibody

orb359168

Human VEGFA

Active Protein

orb10845

HSP27

Antibody

orb50172

Human HSP27

ELISA Kit

orb14551

FAK

Antibody

orb379158

Ras

Antibody


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궁금한 사항은 바이오클론으로 문의해 주세요.

Homepage : www.bioclone.co.kr
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Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. VEGF is produced by several cell types such as fibroblasts, inflammatory cells, and many tumor cells, often in response to increasing tumor hypoxia via the HIF-1a pathway.

Currently, the VEGF family is composed of five structurally related factors: VEGFA (most well characterized and denoted VEGFA165), VEGFB, VEGFC, VEGFD and placenta growth factor (PlGF). The VEGF family members are homodimeric polypeptides although naturally occurring heterodimers of VEGFA and PlGF have been described. The main VEGF receptor on endothelial cells is VEGFR2. VEGFR2 is essential for endothelial cell biology during development and in the adult, in physiology and pathology. More is known about VEGFR2 signaling than for the other VEGF receptors.

In VEGFA165-mediated signal transduction of VEGFR2, the coordinated arrangement of endothelial cells in three dimensions to form and maintain a vascular tube requires endothelial cell proliferation, migration, survival, and permeability. These biological responses are mediated mainly by VEGFA-activated VEGFR2, via a complex network of intracellular signal transduction pathways. On VEGFA-binding to extracellular Ig-like domains 2 and 3 of VEGFR2, signaling molecules bind to phosphorylation sites in the intracellular domain of VEGFR2 and activate downstream mediators resulting in biological responses such as proliferation, migration, survival and permeability.

Activation of the VEGF pathway has been identified in many disease processes ranging from cancer to autoimmunity, retinopathy and many more. The development of highly specific inhibitors of both the VEGF ligand (bevacizumab, VEGF-Trap, ranibizumab) as well as the VEGF receptor (cediranib, pazopanib, sorafenib, sunitinib, vandetanib, axitinib, telatinib, semaxanib, motesanib, vatalanib, Zactima) relates to the central role that this pathway plays in disease.

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