[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보  |  e브릭몰e브릭몰 회원가입   로그인
BRIC홈 Bio마켓
웨비나모집
스폰서배너광고 안내  배너1 배너2 배너3
전체보기 할인행사 시약벤더 제품평가 기업정보 BRIC인증마크
 
조회 149  인쇄하기 주소복사 트위터 공유 페이스북 공유 
[엘바이오시스템] Ion Channels | News & Updates
제품(기술)분류: 시약 > Antibody
전화: 031-229-3350
메일: lbs_reagents(at).daum.net
팩스: 031-229-3351

확대보기
상세정보 사용후기 회사정보 |  등록제품 |  시약벤더 |  진행중 이벤트
  카탈로그 NO :
  제품 생산일 : 년도 선택.월 선택
  원산지 :
  생산기업 : Alomone lab
  특징 및 규격  
 
   
Products for Immuno-Colocalization
 
 
Alomone Labs has developed three innovative product lines for studying protein-protein interaction and/or protein co-localization:
Primary antibodies conjugated to biotin or ATTO-fluorescent dyes: These antibodies can be used in immunohistochemistry (IHC) and immunocytochemistry (ICC) with same species antibodies.
Antibodies raised in guinea pig: These second species antibodies can be used with any other non-guinea pig second species antibodies in immuno-colocalization studies such as IHC and ICC.
Toxins conjugated to ATTO-fluorescent dyes: These labeled toxins can be used with any antibody to obtain highly specific channel localization.
 

Guinea pig Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGP-083)

Expression of GABA(A) α1 Receptor in rat hippocampus:
AGP-083

Anti-TRPV4-ATTO-550 Antibody
(#ACC-034-AO)

 
Expression of TRPV4 in rat DRG:
ACC-034-AO
 
 

Anti-Presenilin-1-ATTO-488 Antibody (#AIP-011-AG)

Immuno-colocalization of Calnexin and Presenilin-1 in mouse cortex:
 
AIP-011-AG
 
 
Products for Live Cell Flow Cytometry
 
 
We put in tremendous effort in designing antibodies that recognize extracellular domains of proteins.
With Alomone Labs extracellular antibodies:
No need for cell permeabilization and fixation
Cell surface detection of proteins
 

Anti-Anoctamin-6 (extracellular)-FITC Antibody (#ACL-016-F)

Cell surface detection of ANO6 in live intact mouse P815 mastocytoma cells:
ACL-016-f

Anti-KV1.3 (KCNA3) (extracellular)-PE Antibody (#APC-101-PE)

Cell surface detection of KV1.3 in human Jurkat T-cell leukemia cells:
APC-101-PE
 
Products for Live Cell Imaging (LCI)
 
 
Alomone Labs is committed to developing cutting edge reagents for visualizing ion channels in live cell imaging (LCI) experiments. For this purpose we have established a line of antibodies recognizing extracellular epitopes of various ion channels. Below are new antibodies ideal for LCI.
 

Anti-Pannexin 2 (extracellular) Antibody (#ACC-232)

 
Cell surface detection of Pannexin 2 in live intact human U-87 MG glioblastoma cells:
ACC-232

Anti-Nicotinic Acetylcholine Receptor α2 (CHRNA2) (extracellular) Antibody
(#ANC-002)

Cell surface detection of nAChRα2 in live intact rat PC12 pheochromocytoma cells:
anc-002
 
 

Anti-NaV1.7 (SCN9A) (extracellular) Antibody (#ASC-027)

Cell surface detection of NaV1.7 in intact living rat pheochromocytoma PC12 cells:
 
ASC-027
 
 
Labeled Toxins as Probes for Detecting Ion Channels
 
 
Studying membrane proteins, namely ion channels, remains a challenge due to the nature of their complex structure. Using the unique and exclusive properties of peptide toxins, we have developed a novel tool for detecting ion channels in living cells and tissues.
 
Benefits of using labeled toxins:
Localization and distribution
Clustering and internalization kinetics
Live cell imaging
Single cell detection
Binding kinetics
 
A Bit of Color Goes a Long Way
 

MmTx1 Toxin-ATTO-488 (#STM-550-AG)

bioassay
 
STM-550-AG
Purity: >99%
Target: Agonist of GABA(A) receptors
 
Alomone Labs MmTx1 Toxin-ATTO-488 labels GABA(A) α1 receptor in rat cerebellum:
 
STM-550-AG
 
 
 
Alomone Labs MmTx1 Toxin ATTO-488 binds to rat cerebellum:
 
STM-550-AG
 

 

We gladly take on collaboration projects. Please contact us.
 
Ion Channel Products in Featured Papers
 
 

A Potential Role for Kir5.1 Channel in pH Sensitivity in 5-HT Neurons

Serotonin (5-HT) neurons in the brain stem play an important role in maintaining/modulating ventilation and pH sensitivity for proper functioning of the neural network.

A search of age-related changes of pH-sensitive molecules in 5-HT neurons gave rise to the identification of Kir5.1 channel as a potential candidate in CO2/pH chemosensitivity in brainstem 5-HT neurons. Immunohistochemical staining of rat brainstem sections using Anti-Kir4.1 (KCNJ10) Antibody (#APC-035) and Anti-Kir5.1 Antibody (#APC-123) showed that both channels are expressed (green). However, Kir4.1 staining is limited to astrocytes, while that of Kir5.1 is detected in 5-HT neurons (Figure 1).

The authors do not rule out the possibility that other proteins, namely pH-sensitive ion channels may also be involved.

 

Figure 1. Expression of Kir4.1 and Kir5.1 channels in rat brainstem:
 
APC-123
 
Adapted from Puissant, M.M. et al. (2017) Front. Cell. Neurosci. 11, 34. with permission of Frontiers.
 

 

https://www.alomone.com/   

http://lbiosystems.co.kr/     

 

 

 

사용후기
작성자*
내용*
만족도*
아이빔테크놀로지
제품평가 공지사항
수입 외산제품 제품평가를 시작합니다.
할인행사 광고 할인행사 광고
마크로텍
에펜도르프코리아 Ezscope Nikon 현미경 마이크로톰 특가판매
엠피바이오메디칼스코리아
에펜도르프코리아 샘플파쇄 단 40초! 비드호모게나이저 특별할인행사: 가격할인+사은품 증정
위로가기
Bio마켓 홈  |  Bio마켓FAQ  |  Bio마켓 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북   유튜브 유튜브    RSS서비스 RSS
머크