[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보  |  e브릭몰e브릭몰 회원가입   로그인
BRIC홈 동향
실험복 제공
스폰서배너광고 안내  배너1 배너2 배너3
전체보기 뉴스 Bio통신원 Bio통계 BRIC View BRIC이만난사람들
추천7  조회7617  소셜네트워크로 공유하기
 BioWave, Vol., No., SubNo.1
Finding Regulatory Logic in the Genome
이창희, 이동원

Johns Hopkins School of Medicine

To whom correspondence should be addressed. E-mail : deepsilence(at).jhmi.edu

Various approaches and technologies have emerged to understand the functional regulatory elements in the genome. They provide rich resources to biomedical researchers in better understanding the systems aspect of biology. However, the underlying approaches, assumptions and strengths and weaknesses are often less appreciated. Here we overview two general approaches that tackle the problem of identifying functional regulatory elements. The first approach is to infer regulatory elements de novo from similarity of expression or homology within phylogeny. The other approach is to focus on a particular mode of regulatory mechanism and construct a biophysical model based on high-throughput genome-wide data to predict interaction. A notable example is the prediction of transcription factor binding sites (TFBS). Practical resources, such as major databases and prediction algorithms are briefly evaluated as guides for general researchers.

JHIBRG Home Page


Category : Medicine
 
(이 자료는 BRIC IP Johns Hopkins Interdisciplinary Biomedical Research Group에서 제공하였습니다.)
 
Citation: 이창희(2009). Finding Regulatory Logic in the Genome. BioWave, (): 1. Available from https://www.ibric.org/myboard/read.php?Board=review0&id=2420 (Apr 03, 2009)
라이카코리아
이달의 웹진
이달의 웹진   BRIC View
기획특집
BioLab
BOOK
지난호
위로가기
동향 홈  |  동향FAQ  |  동향 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북   유튜브 유튜브    RSS서비스 RSS
머크