한빛사 논문
Abstract
( aminoacyl-tRNA synthetase | glucagon | pancreas )
Sang Gyu Park *, Young Sun Kang *, Jin Young Kim *, Chang Seok Lee , Young Gyu Ko , Woo Je Lee , Ki-Up Lee , Young Il Yeom , and Sunghoon Kim *¶
*National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Seoul 151-742, Korea; Division of Life Sciences and Graduate School of Biotechnology, Korea University, 1, 5-ga, Anam-dong, Sungbuk-gu, Seoul 136-701, Korea; Department of Internal Medicine, University of Ulsan College of Medicine, Seoul 138-736, Korea; and Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-333, Korea
Edited by Lewis T. Williams, Five Prime Therapeutics, San Francisco, CA, and approved August 2, 2006 (received for review March 14, 2006)
AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.
Author contributions: S.G.P., K.-U.L., Y.I.Y., and S.K. designed research; S.G.P., Y.S.K., J.Y.K., C.S.L., and Y.G.K. performed research; Y.G.K. contributed new reagents/analytic tools; S.G.P., W.J.L., and K.-U.L. analyzed data; and S.G.P. and S.K. wrote the paper.
The authors declare no conflict of interest.
¶To whom correspondence should be addressed.
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