The mTRAQ® Reagents are amine-specific, stable isotope labeled reagents, available in duplex or triplex format, designed for high confidence protein and peptide biomarker verification using MRM analysis on QTRAP® systems and the Triple Quadrupole Mass Spectrometers.
The use of the triplex chemistry will increase sample throughput by 100%.
Duplex or triplex mass difference tags (Non-Isobaric Amine Tags)
Established chemistry with > 95% labeling efficiency
High selectivity MRM based relative quantitation of proteins/peptides/PTMs
Supports Global Internal Standard workflow for robust reproducible quantitative MRM assays in biomarker verification
Compatible with fractionation
Easy transition from iTRAQ® reagent based discovery to verification.
Significantly more economical compared to stable isotope labeled synthetic peptide approach for biomarker verification when larger numbers of peptides need to be monitored
Supported by complete suite of software for biomarker verification, including ProteinPilot™ Software, MRMPilot™ Software, and MultiQuant™ Software