연구용제품시약 > Chemical Reagent
Inhibitors for JAK/STAT [AG Scientific 한국독점대리점 ]
바이오클론
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
ISO 9001:2008 인증제조 업체 A.G. scienticfic사는 High Quality 시약을 공급합니다. ★ Small size, Bulk size 공급가능. 기타 Products 는 www.agscientific.com을 참조 하세요. 금요일 5시 발주 |
본 정보는 "바이오클론" (으)로 문의 바랍니다.