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Weekly Research Highlights (2010.02.18)
종합 BRIC (2010-02-18)
Research Highlights from the Nature
Note : "Research Highlights" picks up important thesis and introduces summary of the thesis. Those thesis must be "new" and presented on "innovative research results".
매주 발간되는 네이처(Nature) 및 네이처 자매지에서는 각호에서 전세계 다양한 전문 연구개발 분야에서 학문적 성과가 뛰어나고 최신 신기술로서 향후 주목할 만한 가치가 매우 높은 학술 논문을 엄선하여 전세계 과학자 및 관련분야 연구자에게 소개하고 있습니다. 이 중 바이오관련 연구논문을 모아 소개합니다.

Ecology: why horses wear white
Proc. R. Soc. B doi:10.1098/rspb.2009.2202 (2010)
An unexpected advantage of whiteness in horses: the most horsefly-proof horse has a depolarizing white coat
White horses frequently suffer from malign skin cancer and visual deficiencies owing to their high sensitivity to the ultraviolet solar radiation. Furthermore, in the wild, white horses suffer a larger predation risk than dark individuals because they can more easily be detected. In spite of their greater vulnerability, white horses have been highly appreciated for centuries owing to their natural rarity. Here, we show that blood-sucking tabanid flies, known to transmit disease agents to mammals, are less attracted to white than dark horses...More

Genetics: Two strikes
Nature Genet. doi:10.1038/ng.534 (2010)
A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay
We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls (P = 0.0009, OR = 7.2) and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls (P = 0.028, OR = 2.5). Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents (P = 0.037, OR = 6)...More

Neurobiology: The science of silence
Neuron 65, 412-421 (2010)
Nonoverlapping Sets of Synapses Drive On Responses and Off Responses in Auditory Cortex
Neurons in visual, somatosensory, and auditory cortex can respond to the termination as well as the onset of a sensory stimulus. In auditory cortex, these off responses may underlie the ability of the auditory system to use sound offsets as cues for perceptual grouping. Off responses have been widely proposed to arise from postinhibitory rebound, but this hypothesis has never been directly tested. We used in vivo whole-cell recordings to measure the synaptic inhibition evoked by sound onset. We find that inhibition is invariably transient, indicating that off responses are not caused by postinhibitory rebound in auditory cortical neurons...More

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