한국 독점 대리점:바이오클론    (주) ( www.bioclone.co.kr )

* 20만여개의 제품 보유
* Alexa Flour/350/488/555/594/647, Cy3/5/5.5/7, FITC, HRP, PE 등의 다양한 Fluorescence Dye와 conjugation된 antibody 제공
* WB, ELISA, IHC-P, IF, FCM 등의 다양한 Application

https://www.biossusa.com/products/bskh1008

Human IL-8 ELISA Kit

BSKH1008

TARGET INFORMATION

Interleukin 8 (IL-8), a member of the neutrophil-specific CXC subfamily of chemokines, is a potent neutrophil chemotactic and activating factor. It is a primary inflammatory cytokine produced by many cells including monocytes/ macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, astrocytes and chondrocytes. It is in response to proinflammatory stimuli such as IL-1, TNF, LPS and viruses. Its function is, in part, to attract neutrophils to the site of inflammation and to activate them.

The human IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa). Further proteolysis of the N-terminal end leads to a variant form with 72 amino acids; full activation of IL-8 may require cleavage to the 72 amino acid form.

IL-8 can form non-covalent dimers in solution, especially at high concentrations, but dimerization is not necessary for biological activity. IL-8 binds to two seven-transmembrane, G protein-coupled receptors, CXCR1 and CXCR2, as well as to the non-signalling Duffy antigen on red-blood cells. The Duffy antigen may play a role in regulating IL-8 activity on functional receptors.

MATERIALS SUPPLIED

STORAGE

https://www.biossusa.com/products/bskh1008