연구용제품시약 > Kit
[Epigentek] Oxidative Stress Damage Assays
부경S·M
Oxidative stress damage plays an important role in the etiology and progression of a multitude of human pathologies, including oncologic, cardiovascular, and autoimmune diseases and disorders. Through reactive oxygen species (ROS), oxidative stress can result in cellular damage, enzyme inactivation, and epigenetic impairment of DNA. A better understanding of oxidative stress damage—disease relationships can therefore be beneficial for diagnostic and therapeutic purposes. As a consequence, various biomarkers have been identified for oxidative stress damage, with the most well-studied being: oxidized nucleoside derivatives like 8-hydroxy-2’-deoxyguanosine (8-OH-dG) and 8-hydroxyguanosine (8-OH-G) that are generated by ROS in cellular DNA and RNA, respectively; the ROS hydrogen peroxide (H202) and its catalyzing enzyme superoxide dismutase (SOD); and histone H2AX phosphorylation, particularly at serine 139, which manifests during the DNA damage response.
Most available methods used to investigate these biomarkers are time-consuming and have low throughput, low accuracy, and high costs. By leveraging its EpiQuik™ technologies, EpiGentek has developed a series of innovative research tools to address those issues. Our comprehensive product suite for oxidative stress damage assessment includes the following features and advantages:
Detect & Quantify Oxidative DNA Damage (8-OHdG) Directly from DNA
A few notable benefits include:
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Colorimetric-based quantitation of 8-OH-dG in DNA samples (LOD = 2 pg of 8-OH-dG)
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Fluorometric assay for quantitating 8-OH-dG in DNA samples (LOD = 1 pg of 8-OH-dG)
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Directly Detect Oxidative RNA Damage (8-OhG) Status Using RNA
A few notable benefits include:
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Description
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Colorimetric-based quantitation of 8-OH-G in RNA samples (LOD = 2 pg of 8-OH-G)
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Fast & Sensitive DNA Damage Measurement from Various Cells or Tissues
A few notable benefits include:
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Fast and sensitive measurement of H2O2 from various samples, including living cells, cell/tissue extracts, and body fluids
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Detects SOD activity in cell/tissue extracts by measuring color production of a reaction mediated by the SOD substrate superoxide anion
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Detect DNA Damage In-Situ from Various Samples
A few notable benefits include:
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Description
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Detects DNA damage or apoptosis by measuring phospho-H2AX (Ser139) in cultured adherent cells
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Fast and sensitive measurement of H2O2 from various samples, including living cells, cell/tissue extracts, and body fluids
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