HUABIO
https://www.huabio.com/
바이오클론은 HUABIO의 국내 독점 대리점으로
합리적인 가격으로 다양한 HUABIO의 Antibody를 공급하고있습니다.
(다양한 Antibody 30~40만원대/VAT)
APOER2 Mouse Monoclonal Antibody [13B2]
APPLICATIONS
REACTIVITY
SPECIFICATIONS
PRODUCT TYPE
Mouse monoclonal primary
PRODUCT NAME
APOER2 Mouse Monoclonal Antibody [13B2] (EM1902-30)
IMMUNOGEN
Recombinant protein within human apoer2 aa 47-275 / 963.
HOST
Mouse
POSITIVE CONTROL
A549 cell lysate, SHSY5Y cell lysate, SKBR-3 cell lysate, U937 cell lysate, SKOV-3.
CONJUGATION
Unconjugated
CLONALITY
Monoclonal
CLONE NUMBER
13B2
PROPERTIES
FORM
Liquid
STORAGE CONDITION
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
STORAGE BUFFER
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
CONCENTRATION
2 ug/ul
PURIFICATION
Protein A purified
MOLECULAR WEIGHT
Predicted band size: 106/78/99/87 kDa
ISOTYPE
IgG2a
APPLICATION DILUTION
TARGET
UNIPROT #
Q14114
PROTEIN NAME
APOER2
SYNONYMS
APOER2 antibody; Apolipoprotein E receptor 2 antibody; low density lipoprotein receptor-related protein 8 antibody; Low-density lipoprotein receptor-related protein 8 antibody; LRP-8 antibody; LRP8 antibody; LRP8_HUMAN antibody
SEQUENCE SIMILARITIES
Belongs to the LDLR family.
TISSUE SPECIFICITY
Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.
POST-TRANSLATIONAL MODIFICATION
O-glycosylated. Some alternatively spliced isoforms lack the O-linked sugar domain (By similarity).; Undergoes sequential, furin and gamma-secretase dependent, proteolytic processing, resulting in the extracellular release of the entire ligand-binding domain as a soluble polypeptide and in the intracellular domain (ICD) release into the cytoplasm. The gamma-secretase-dependent proteolytical processing occurs after the bulk of the extracellular domain has been shed, in a furin-dependent manner, in alternatively spliced isoforms carrying the furin cleavage site. Hypoglycosylation (mainly hypo-O-glycosylation) leads to increased extracellular cleavage, which in turn results in accelerating release of the intracellular domain (ICD) by the gamma-secretase. The resulting receptor fragment is able to inhibit Reelin signaling and in particular the Reelin-induced DAB1 phosphorylation (By similarity).; Tyrosine phosphorylated upon apoE binding.; Ubiquitinated by MYLIP leading to degradation.
SUBCELLULAR LOCATION
Cell membrane, Membrane, Secreted.
FUNCTION
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity).
Tel : 02)2690-0058 Fax : 02)2690-0397
Homepage : www.bioclone.co.kr
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