HUABIO 

https://www.huabio.com/

바이오클론은 HUABIO의 국내 독점 대리점으로 

합리적인 가격으로 다양한 HUABIO의 Antibody를 공급하고있습니다.

(다양한 Antibody 30~40만원대/VAT)

APPLICATIONS

• WB

• ICC

• IHC-P

• FC

REACTIVITY

• HUMAN

•  

• MOUSE

•  

• RAT

SPECIFICATIONS

PRODUCT TYPE

Rabbit polyclonal primary

PRODUCT NAME

Claudin 18.2 Rabbit Polyclonal Antibody (ER1902-86)

IMMUNOGEN

Synthetic peptide corresponding to n terminal of human cldn18.

HOST

Rabbit

POSITIVE CONTROL

Rat heart tissue lysates, MG-63, human stomach carcinoma tissue, F9.

CONJUGATION

Unconjugated

CLONALITY

Polyclonal

PROPERTIES

FORM

Liquid

STORAGE CONDITION

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

STORAGE BUFFER

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

CONCENTRATION

1 ug/ul

PURIFICATION

Immunogen affinity purified.

MOLECULAR WEIGHT

28 kDa

ISOTYPE

IgG

APPLICATION DILUTION

• WB:1:500-1:2,000

•  

•  

• ICC:1:50-1:200

•  

•  

• IHC-P:1:100-1:500

•  

•  

• FC:1:50-1:100

•  

•  

TARGET

UNIPROT #

P56856

PROTEIN NAME

Claudin 18.2

SYNONYMS

Claudin 18 antibody; Claudin-18 antibody; CLD18_HUMAN antibody; CLDN18 antibody; SFTA5 antibody; SFTPJ antibody

SEQUENCE SIMILARITIES

Belongs to the claudin family.

TISSUE SPECIFICITY

Isoform A1: Expression is restricted to the lung. Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level).

SUBCELLULAR LOCATION

Cell membrane, tight junction.

FUNCTION

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Tel : 02)2690-0058 Fax : 02)2690-0397
Homepage : www.bioclone.co.kr