한빛사 논문
Abstract
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and Department of Chemistry, Purdue University, West Lafayette, Indiana 47907
Chem. Rev., 2009, 109 (6), pp 2275–2314
DOI: 10.1021/cr800365m
Publication
Date (Web): May 13, 2009
Copyright © 2009 American Chemical Society
† This review is dedicated to the community of isolation/identification natural product detectives, with special thanks to the groups of Bob Pettit and Nobuhiro Fusatani., ‡ Harvard University., § Purdue University., * Corresponding author.
1. Introduction
The search for natural products of medicinal significance led the Pettit group to isolate the cephalostatins1 (from the hemichordate worm Cephalodiscus gilchristi,2 e.g., cephalostatin 1 (1)) and the Fusetani team to isolate the ritterazines3 (from the tunicate Ritterella tokioka, e.g., ritterazine B (2)), respectively. The cephalostatins and ritterazines are a family of 45 trisdecacyclic bissteroidal pyrazines that display striking cytotoxicity against human tumors (∼1 nM in the 2-day NCI 60 cell panel,4 and in some cases, ∼10 fM 6-day in the Purdue mini panel5), thereby ranking them among the most potent anticancer agents tested by the NCI....
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