CELL SIGNALLING AND THE CONTROL OF PRE-mRNA SPLICING
Chanseok Shin & James L. Manley
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
The transcripts of most metazoan protein-coding genes are alternatively spliced, but the mechanisms that are involved in the control of splicing are not well understood. Recent evidence supports the potential of both extra- and intracellular signalling to the splicing machinery as a means of regulating gene expression, and indicates that this form of gene control is widespread and mechanistically complex. However, important questions about these pathways need to be answered before this method of post-transcriptional regulation can be fully appreciated.