한빛사 논문
Eunji Kong1,2,3,5, Kyu-Hee Lee1,5, Jongrok Do1,4, Pilhan Kim2,3 & Doyun Lee1
1Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea.
2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
3KI for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
4Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
5These authors contributed equally: Eunji Kong, Kyu-Hee Lee.
Corresponding authors : Correspondence to Pilhan Kim or Doyun Lee.
Abstract
Recognizing an individual and retrieving and updating the value information assigned to the individual are fundamental abilities for establishing social relationships. To understand the neural mechanisms underlying the association between social identity and reward value, we developed Go-NoGo social discrimination paradigms that required male subject mice to distinguish between familiar mice based on their individually unique characteristics and associate them with reward availability. We found that mice could discriminate individual conspecifics through a brief nose-to-nose investigation, and this ability depended on the dorsal hippocampus. Two-photon calcium imaging revealed that dorsal CA1 hippocampal neurons represented reward expectation during social, but not non-social tasks, and these activities were maintained over days regardless of the identity of the associated mouse. Furthermore, a dynamically changing subset of hippocampal CA1 neurons discriminated between individual mice with high accuracy. Our findings suggest that the neuronal activities in CA1 provide possible neural substrates for associative social memory.
논문정보
관련 링크
연구자 ID
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기