한빛사 논문
Sijia Wua, Zhiwei Fanb,c, Pora Kimc, Liyu Huanga, Xiaobo Zhouc
aSchool of Life Science and Technology, Xidian University, Xi’an 710071, China
bWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610040, China
cCenter for Computational Systems Medicine, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Corresponding authors: Pora Kim, Liyu Huang, Xiaobo Zhou
Abstract
Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers. However, the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient. To fill this gap, we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer types from The Cancer Genome Atlas. For individual candidate among ∼ 1.5 M quantified RNA editing events, we performed diverse types of down-stream functional annotations. Finally, we identified 24,236 potentially functional A-to-I RNA editing events, including the cases in APOL1, IGFBP3, GRIA2, BLCAP, and miR-589-3p. These events might play crucial roles in the scenarios of tumorigenesis, due to their tumor-related editing frequencies or probable effects on altered expression profiles, protein functions, splicing patterns, and microRNAs regulations of tumor genes. Our functional A-to-I RNA editing events (https://ccsm.uth.edu/CAeditome/) will help better understanding of cancer pathology from A-to-I RNA editing aspect.
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