한빛사 논문
Rosie Kwon # 1 2, Youn Ho Shin # 3, Jae Il Shin # 4, So Min Kang 5, Jimin Hwang 6, Jung U Shin 7, Hyungrye Noh 8, Chan Yeong Heo 9, Ai Koyanagi 10 11, Louis Jacob 10 12, Lee Smith 13, Jonas F Ludvigsson 14 15 16, Stephen Turner 17, Ju-Young Shin 18 19, Han Eol Jeong 18, Jung-Hyun Kim 20, Sang Youl Rhee 2 21, Chanyang Min 2, Dong In Suh 22, Min Ji Koo 2 23, Katrina Abuabara 24, Sunyeup Kim 25, Seung Won Lee 25, Dong Keon Yon 2 26, Seong Ho Cho 27
1Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
2Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
3Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea.
4Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
5Research Administration Team, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
6Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
7Department of Dermatology, CHA Bundang Mediacal Center, CHA University School of Medicine, Seongnam, Republic of Korea.
8Department of Dermatology, Samsung Mediacal Center, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea.
9Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
10Research and Development Unit, Parc Sanitari Sant Joan de Deu, CIBERSAM, Barcelona, Spain.
11Catalan Institution for Research and Advanced Studies (ICREA), Pg. Lluis Companys, Barcelona, Spain.
12Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
13Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
14Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
15Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.
16Department of Paediatrics, Örebro University Hospital, Sweden.
17Maternity and Child Health Division, NHS Grampian Aberdeen, UK.
18School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
19Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Republic of Korea.
20Department of Allergy and Clinical Immunology, Korean Armed Forces Capital Hospital, Seongnam, Republic of Korea.
21Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Republic of Korea.
22Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
23Department of Human Biology, University of Toronto, Toronto, Ontario, Canada.
24Program for Clinical Research, Department of Dermatology, University of California, San Francisco, CA, USA.
25Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
26Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, South Korea.
27Division of Allergy-Immunology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
#Contributed equally.
These authors were contributed equally : Rosie Kwon, Youn Ho Shin, Jae Il Shin
CORRESPONDING AUTHOR : Seung Won Lee, Dong Keon Yon
Abstract
Globally, the prevalence of food allergy (FA) in children is increasing, and FA can induce fatal anaphylaxis, which affects morbidity and mortality.1,2 Children with FAs are more likely to have food neophobia, which may lead to severe vitamin D deficiency and osteoporosis. Although some studies suggested milk avoidance specifically, which leads young children to be prone to bone fracture3, no studies have investigated whether children with FAs are at increased risk of fracture, and hence there is a need to determine the direct association between FA and fracture incidence during childhood. We hypothesized that FAs are linked with an increased risk of fracture. Therefore, the relationship between FA diagnosis and fracture incidence in approximately two million children was examined in this representative large-scale nationwide birth cohort from the National Health Insurance Service in South Korea.
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