한빛사 논문
Yun-Nam Choi1†, Namjin Cho1†, Kanghun Lee2, Da-ae Gwon1, Jeong Wook Lee1, 2*, and Joongoo Lee1, 2*
†These authors contributed equally to this work: Yun-Nam Choi and Namjin Cho
1 Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea
2 School of Interdisciplinary Bioscience and Bioengineering (I-Bio), Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea
Corresponding authors: Jeong Wook Lee and Joongoo Lee
Abstract
Motivated by the intricate mechanisms underlying biomolecule syntheses in cells that chemistry is currently unable to mimic, researchers have harnessed biological systems for manufacturing novel materials. Cell-free systems (CFSs) utilizing the bioactivity of transcriptional and translational machineries in vitro are excellent tools that allow supplementation of exogenous materials for production of innovative materials beyond the capability of natural biological systems. Herein, recent studies that have advanced the ability to expand the scope of biobased materials using CFS have been summarized and approaches enabling the production of high-value materials, prototyping of genetic parts and modules, and biofunctionalization have been discussed. By extending the reach of chemical and enzymatic reactions complementary to cellular materials, CFSs provide new opportunities at the interface of materials science and synthetic biology.
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