한빛사 논문
Gihyeon Kim1,2†, Youngmin Yoon3†, Jin Ho Park4†, Jae Won Park2†, Myung‑guin Noh1, Hyun Kim1, Changho Park2, Hyuktae Kwon4, Jeong‑hyeon Park2, Yena Kim2, Jinyoung Sohn2, Shinyoung Park2, Hyeonhui Kim5, Sun‑Kyoung Im5, Yeongmin Kim1, Ha Yung Chung6, Myung Hee Nam6, Jee Young Kwon7, Il Yong Kim8,9, Yong Jae Kim9, Ji Hyeon Baek9, Hak Su Kim9, George M. Weinstock7, Belong Cho4†, Charles Lee7,10,11†, Sungsoon Fang5*, Hansoo Park1,2* and Je Kyung Seong8,9,12*
1 Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
2 Genome and Company, Pangyo‑ro 255, Bundang‑gu, Seongnam, Korea.
3 Division of Nephrology, Department of Medicine, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea.
4 Department of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
5 Graduate school of Medical Science, Brain Korea 21 Project, Severance Biomedical Science Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
6 Korea Basic Science Institute, Seoul Center, Seoul, South Korea.
7 The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032, USA.
8 Laboratory of Developmental Biology and Genomics, BK21 Plus Program for Advanced Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
9 Korea Mouse Phenotyping Center, Seoul National University, Seoul, Korea.
10 Department of Life Science, Ewha Womans University, Seoul 03760, Korea.
11 The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China.
12 Interdisciplinary Program for Bioinformatics, Seoul National University, Seoul, Korea.
†Gihyeon Kim, Youngmin Yoon, Jin Ho Park, and Jae Won Park equally contributed to this work.
†Belong Cho and Charles Lee are co-senior authors.
*Correspondence: Sungsoon Fang, Hansoo Park and Je Kyung Seong
Abstract
Background: Comparisons of the gut microbiome of lean and obese humans have revealed that obesity is associated with the gut microbiome plus changes in numerous environmental factors, including high-fat diet (HFD). Here, we report that two species of Bifidobacterium are crucial to controlling metabolic parameters in the Korean population.
Results: Based on gut microbial analysis from 99 Korean individuals, we observed the abundance of Bifidobacterium longum and Bifidobacterium bifidum was markedly reduced in individuals with increased visceral adipose tissue (VAT), body mass index (BMI), blood triglyceride (TG), and fatty liver. Bacterial transcriptomic analysis revealed that carbohydrate/nucleoside metabolic processes of Bifidobacterium longum and Bifidobacterium bifidum were associated with protecting against diet-induced obesity. Oral treatment of specific commercial Bifidobacterium longum and Bifidobacterium bifidum enhanced bile acid signaling contributing to potentiate oxidative phosphorylation (OXPHOS) in adipose tissues, leading to reduction of body weight gain and improvement in hepatic steatosis and glucose homeostasis. Bifidobacterium longum or Bifidobacterium bifidum manipulated intestinal sterol biosynthetic processes to protect against diet-induced obesity in germ-free mice.
Conclusions: Our findings support the notion that treatment of carbohydrate/nucleoside metabolic processes-enriched Bifidobacterium longum and Bifidobacterium bifidum would be a novel therapeutic strategy for reprograming the host metabolic homeostasis to protect against metabolic syndromes, including diet-induced obesity. Video Abstract.
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