한빛사 논문
Nahyun Kwon a,1, Kwang H. Kim b,1, Sinyoung Park c,1, Yejin Cho b, Eun-Yeong Park c, Junha Lim d, Seda Çetindere f, Süreyya Oguz Tümay f, Won Jong Kim d, Xingshu Li e,*, Ki Taek Nam b,*, Chulhong Kim c,*, Serkan Yesilot f,*, Juyoung Yoon a,*
a Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea b Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea c Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, and Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea d Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea e College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China f Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey
* Corresponding authors.
1 These authors contributed equally to this work.
Abstract
Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, ‘safe’ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.
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