한빛사 논문
Sung Kook Chun1†, Bridget M. Fortin1†, Rachel C. Fellows1†, Amber N. Habowski2, Amandine Verlande1, Wei A. Song1, Alisa L. Mahieu1, Austin E. Y. T. Lefebvre3, Jason N. Sterrenberg4, Leandro M. Velez1, Michelle A. Digman3, Robert A. Edwards5, Nicholas R. Pannunzio4, Marcus M. Seldin1, Marian L. Waterman2, Selma Masri1*
1Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA. 2Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA. 3Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA. 4Department of Medicine, University of California, Irvine, Irvine, CA 92697, USA. 5Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA.
*Corresponding author.
†These authors contributed equally to this work.
Abstract
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of young onset CRC include environmental aspects, such as lifestyle and dietary factors, which are known to affect the circadian clock. We find that both genetic disruption and environmental disruption of the circadian clock accelerate Apc-driven CRC pathogenesis in vivo. Using an intestinal organoid model, we demonstrate that clock disruption promotes transformation by driving Apc loss of heterozygosity, which hyperactivates Wnt signaling. This up-regulates c-Myc, a known Wnt target, which drives heightened glycolytic metabolism. Using patient-derived organoids, we show that circadian rhythms are lost in human tumors. Last, we identify that variance between core clock and Wnt pathway genes significantly predicts the survival of patients with CRC. Overall, our findings demonstrate a previously unidentified mechanistic link between clock disruption and CRC, which has important implications for young onset cancer prevention.
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