한빛사 논문
Ji-Yong Sung1 Jae-Ho Cheong2,3,4
1Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea 2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea 3Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul, Korea 4Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Korea
Correspondence Ji-Yong Sung, Jae-Ho Cheong
Abstract
Dear Editor
Prognostic markers in gastric cancer1 are not only used to clinically classify patients into groups but are also being studied extensively for assessing cancer progression and drug development. Hence, the mechanisms by which genes associated with different prognoses in gastric cancer affect stem-like molecular subtypes require further investigation. We selected the top 500 genes with significantly different prognostic values for stomach adenocarcinoma in The Cancer Genome Atlas (TCGA) (Figure 1A, Table S1). The genes differed significantly between the high and low expression samples (Figure 1B). Most of these 500 genes were enriched during synapse assembly, trans-synaptic signalling, and developmental growth (Figure 1C)...
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