한빛사 논문
Da In Jeong a, Sungyun Kim a, Song Yi Lee a,b, Han-Jun Kim c, Junmin Lee c,d, KangJu Lee c,e, Hyun-Jong Cho a,*
a Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea b Kangwon Institute of Inclusive Technology, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea c Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA d Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea e School of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59626, Republic of Korea
*Corresponding author.
Abstract
Glucose deprivation, hydroxyl radical generation, photothermal ablation, and ferroptosis induction-installed injectable hydrogel reactor was designed for multiple therapy of localized breast cancer. Iron sulfate (IS) was introduced to hydrogel reactor network for coordination with catechol groups of hyaluronic acid-catechol (HC) conjugate, photothermal conversion by reaction with catechols, Fenton-reaction-related hydroxyl radical production, and ferroptosis induction of cancer cells. Glucose oxidase (GOx) was incorporated in hydrogel reactor for the decomposition of glucose and production of H2O2. Following curing strategies were elaborately organized in the one-pot hydrogel reactor structure: i) starvation of cancer cells and self-supply of H2O2 by GOx, ii) hydroxyl radical generation (from H2O2) and ferroptosis induction by IS, and iii) photothermal therapy by catechol polymerization and iron ion-catechol binding. Exquisite arrangement of therapeutic modalities in HC-based hydrogel network by local injection to breast cancer was applied in this study. Also, the rheological properties of HC hydrogel were tuned by pH adjustment for endowing immediate and uniform gelation features, injection through single syringe, shear-thinning behaviors, and self-healing characteristics. It is expected that fabricated hydrogel reactor system can be used efficiently and safely for curing cancers following its local injection.
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