한빛사 논문
Siyoung Haa,1, Jinyeong Kima,1, Chul Soon Parka,f, Sangwoo Leeb, Donggon Yoob,c, Kyung Ho Kima, Sung Eun Seoa, Seon Joo Parka, Jai Eun Ana, Hyun Seok Songd, Joonwon Baee, Woo-Keun Kimb,c,**, Oh Seok Kwona,g,*
aInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea bBiosystem Research Lab, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea cHuman and Environmental Toxicology, University of Science and Technology, Daejeon, 34113, Republic of Korea dSensor System Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea eDepartment of Applied Chemistry, Dongduk Women’s University, Seoul, 02748, Republic of Korea fProcess Development Team, Drug Manufacturing Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, 41061, Republic of Korea gNanobiotechnology and Bioinformatics (Major), University of Science & Technology (UST), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea
*Corresponding author.
**Corresponding author.
1These authors contributed equally to this work.
Abstract
Due to the increase in drug-facilitated sexual assault (DFSA) enabled by the illegal use of drugs, there have been constant demands for simple methods that can be used to protect oneself against crime in real life. γ-Hydroxybutyric acid (GHB), a central nervous system depressant, is one of the most dangerous drugs for use in DFSA because it is colorless and has slow physiological effects, which pose challenges for developing in situ, real-time GHB monitoring techniques. In this study, we developed a method for in situ colorimetric GHB detection using various self-protection products (SPPs) coated with 2-(3-bromo-4-hydroxystyryl)-3-ethylbenzothiazol-3-ium iodide (BHEI) as a chemical receptor embedded in hydrogels. Additionally, smartphone-based detection offers enhanced colorimetric sensitivity compared to that of the naked eye. The developed SPPs will help address drug-facilitated social problems.
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