한빛사 논문
So Yeon Ahn, Jeonghun Kim, Srivithya Vellampatti, Sung Oh, Yong Taik Lim, Sung Ha Park, Dan Luo, Junho Chung, and Soong Ho Um*
S. Y. Ahn, J. Kim, S. Vellampatti, S. Oh, S. H. Um
Progeneer Incorporation 12, Digital-ro 31-gil, Guro-gu, Seoul 08380, Korea
Y. T. Lim, S. H. Um
School of Chemical Engineering Sungkyunkwan University 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea
Y. T. Lim, S. H. Park, S. H. Um
SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea
S. H. Park
Department of Physics Sungkyunkwan University 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea
D. Luo
Department of Biological and Environmental Engineering Cornell University Ithaca, NY 14850, USA
J. Chung
Department of Biochemistry and Molecular Biology Seoul National University College of Medicine Seoul 03080, Korea
S. H. Um
Biomedical Institute for Convergence at SKKU (BICS) Sungkyunkwan University 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea
S. H. Um
Institute of Quantum Biophysics (IQB) Sungkyunkwan University 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea
S.Y.A., J.K., and S.V. contributed equally to this work.
*Corresponding author.
Abstract
RNA can self-fold into complex structures that can serve as major biological regulators in protein synthesis and in catalysis. Due to the abundance of structural primitives and functional diversity, RNA has been utilized for designing nature-defined goals despite its intrinsic chemical instability and lack of technologies. Here, a robust, free-standing RNA hydrogel is developed through a sequential process involving both ligation and rolling circle transcription to form RNA G-quadruplexes, capable of both catalytic activity and enhancing expression of several proteins in sub-compartmentalized, phase-separated translation environments. The observations suggest that this hydrogel will expand RNA research and impact practical RNA principles and applications.
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