한빛사 논문
Hong Sang Choi1,2†, Ansuja Pulickal Mathew3,4†, Saji Uthaman3,4, Arathy Vasukutty3,4, In Jin Kim2, Sang Heon Suh1,2, Chang Seong Kim1,2, Seong Kwon Ma1,2, Sontyana Adonijah Graham3,4, Soo Wan Kim1,2, In‑Kyu Park3,4*† and Eun Hui Bae1,2*†
1Departments of Internal Medicine, Chonnam National University Medi‑cal School, 160, Baekseo‑ro, Dong‑gu, Gwangju 61469, Republic of Korea. 2Departments of Internal Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea. 3Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, 160, Baekseo‑ro, Dong‑gu, Gwangju 61469, Republic of Korea. 4BioMedical Sciences Graduate Program (BMSGP), Chonnam National Univer‑sity, Hwasun‑gun, Jeollanam‑do, Republic of Korea.
*Correspondence
†Hong Sang Choi and Ansuja Pulickal Mathew contributed equally to this manuscript as frst authors
†In-Kyu Park and Eun Hui Bae contributed equally to this manuscript as correspondence authors
Abstract
Background
The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thus, the vicious cycle between oxidative stress and renal hypoxia critically contributes to the progression of chronic kidney disease and finally, end-stage renal disease. Thus, delivering therapeutic agents to the ROS-rich inflammation site and releasing the therapeutic agents is a feasible solution.
Results
We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn3O4 (dMn3O4) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Hydrophobic dMn3O4 nanoparticles were loaded inside PTC micelles to prevent premature release during circulation and act as a therapeutic agent by ROS-responsive release of loaded dMn3O4 once it reached the inflammation site.
Conclusions
The findings of our study demonstrated the successful attenuation of inflammation and apoptosis in the IRI mice kidneys, suggesting that PTC-M nanozyme could possess promising potential in AKI therapy. This study paves the way for high-performance ROS depletion in treating various inflammation-related diseases.
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