한빛사 논문
Ji-Yong Sung1 Jae-Ho Cheong2,3,4
1Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
2Department of Surgery, Yonsei University College of Medicine, Seoul 03722, Korea
3Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea
4Department of Biochemistry & Molecular Biology, Yonsei University College of Medicine, Seoul 03722, Korea
Correspondence Jae-Ho Cheong
Abstract
Immune-directed therapeutic approaches have changed the paradigm of cancer treatment. The tumor-immune microenvironment [1] is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxygen, nutrient deficiency, acidity, and interactions between multiple cell types. In particular, immune cells in the tumor microenvironment are vulnerable to cellular dysfunctions (because of metabolic reprogramming [2]) and engage in intercellular communications with neighboring cells, thereby contributing to a tolerogenic and incompetent immune environment.
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