한빛사 논문
Junsik Choi1, Eric J. Richards2,*
1Whitehead Institute, Cambridge, MA, USA
2Boyce Thompson Institute, Ithaca, NY, USA
*Corresponding author
Abstract
A principal regulatory hub in the nucleus is the surface defined by the exterior rim of its chromatin core and the inner leaf of the nuclear envelope. Functional dissection of the proteins that reside and act at this interface has been a fruitful entrée to understand how chromatin regulation is integrated with nuclear architecture and dynamics. Work in this area is more advanced in animals compared to fungi and plants, but the report of Tang et al. (2021) in this issue joins other recent studies in plants that are beginning to close the gap. Using proximity labeling and subtractive proteomics approaches in Arabidopsis, the lead author’s team has identified an expanding number of previously uncharacterized proteins that are located in or near the inner nuclear envelope (Tang et al., 2020), and in the process, they have begun to reveal the enormous complexity of the plant nuclear lamina (NL).
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