한빛사 논문
Gi Doo Cha1,2⊥, Wang Hee Lee1,2⊥, Sung-Hyuk Sunwoo1,2⊥, Dayoung Kang1,2, Taegyu Kang1,2, Kyoung Won Cho1,2, Minjeong Kim1,2, Ok Kyu Park1,3, Dongjun Jung1,2, Jongha Lee1,2, Seung Hong Choi1,3,*, Taeghwan Hyeon1,2,*, Dae-Hyeong Kim1,2,4,*
1Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.
2School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
3Department of Radiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
4Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea
⊥G. D. Cha, W. H. Lee, and S.-H. Sunwoo contributed equally to this work.
*To whom correspondences should be addressed.
Abstract
Injectable hydrogels show high potential for in vivo biomedical applications owing to their distinctive mode of administration into the human body. In this study, we propose a material design strategy for developing a multifunctional injectable hydrogel with good adhesiveness, stretchability, and bioresorbability. Its multifunctionality, whereupon multiple reactions occur simultaneously during its injection into the body without requiring energy stimuli and/or additives, was realized through meticulous engineering of bioresorbable precursors based on hydrogel chemistry. The multifunctional injectable hydrogel can be administered through a minimally invasive procedure, form a conformal adhesive interface with the target tissue, dynamically stretch along with the organ motions with minimal mechanical constraints, and be resorbed in vivo after a specific period. Further, the incorporation of functional nanomaterials into the hydrogel allows for various in vivo diagnostic and therapeutic applications, without compromising the original multifunctionality of the hydrogel. These features are verified through theranostic case studies on representative organs, including the skin, liver, heart, and bladder.
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
관련분야 논문보기