한빛사 논문
Yoonsuk Choa, Han-Gyu Baea, Eitan Okunb,c,d, Thiruma V. Arumugama,e,*, Dong-Gyu Joa,f,g,*
aSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea
bThe Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 5290002, Israel
cThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel
dThe Pauld Feder Laboratory on Alzheimer’s Disease Research, Israel
eSchool of Life Sciences, La Trobe University, Bundoora, Victoria, Australia
fSamsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, South Korea
gBiomedical Institute for Convergence, Sungkyunkwan University, Suwon 16419, South Korea
*Corresponding authors
Abstract
Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in the brains of individuals with Alzheimer’s disease (AD)-related pathologies. Aβ has been extensively investigated since the amyloid hypothesis in AD was proposed. Besides Aβ, previous studies on APP and its proteolytic cleavage products have suggested their diverse pathological and physiological functions. However, their roles still have not been thoroughly understood. In this review, we extensively discuss the evolutionarily-conserved biology of APP, including its structure and processing pathway, as well as recent findings on the physiological roles of APP and its fragments in the central nervous system and peripheral nervous system. We have also elaborated upon the current status of APP-targeted therapeutic approaches for AD treatment by discussing inhibitors of several proteases participating in APP processing, including α-, β-, and γ-secretases. Finally, we have highlighted the future perspectives pertaining to further research and the potential clinical role of APP.
Keywords : Amyloid precursor protein, Soluble APPα, APP intracellular domain, Alzheimer’s disease
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기