한빛사 논문
Hyoeun Bang1,2 Jae Soon Park1 Jeong Yeon Kim1 Changhwan Sung1,3 Jinhyeon An1 Dae-Yeon Cho2 Se-Hoon Lee4 Seok Bo Shim5 Jung Kyoon Choi1,2,* Kwoneel Kim5,*
1Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea 2Penta Medix Co., Ltd., Seongnam-si, Gyeonggi-do, Republic of Korea 3Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea 4Department of Health Sciences and Technology, Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea 5Department of Biology, Kyung Hee University, Seoul, Republic of Korea
*Corresponding author.
Abstract
Dear Editor,
The outgrowth of clones not expressing tumour antigens is a well-known immune evasion mechanism of cancer. Here, we defined constitutive neoantigens according to the essentiality of their corresponding genes, which are essentially expressed for tumour growth even under immune selection. Hence, the essentiality of antigen-producing genes may be an important determinant of neoantigen validity in cancer immunotherapy.
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기