한빛사 논문
고려대학교
Van-Nghia Nguyen†,#, Jeongsun Ha†,#, Chang Woo Koh‡,#, Bokyeong Ryu§,#, Gyoungmi Kim†, JaeHak Park§, C-Yoon Kim*,¶, Sungnam Park*,‡, and Juyoung Yoon*,†
†Department of Chemistry and Nanoscience, Ewha WomansUniversity, Seoul 03760, Republic of Korea
‡Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea
§Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul08826, Republic of Korea
¶Department of Veterinary Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
*Corresponding Authors
#These authors contributed equally to this paper
Abstract
Boron-dipyrromethene (BODIPY) dyes have aroused considerable interest in cancer theranostics over the past decade because of robust photochemical properties. Although a large number of BODIPY photosensitizers (PSs) containing heavy atoms have been reported, the development of heavy-atom-free BODIPY PSs for oncologic photodynamic therapy (PDT) has been limited mainly by the uncertainty in intersystem crossing (ISC) mechanisms, unbalanced phototoxic effectiveness and fluorescence quantum yields, and aggregation-caused quenching effects. In addition, the lack of extensive in vivo studies of heavy-atom-free BODIPY PSs continues to limit clinical application. Herein, novel heavy-atom-free BODIPY-phenoxazine triads (BDP-8/BDP-9) that generate efficient excited triplet states via radical pair intersystem crossing (RP-ISC) followed by triplet charge recombination were developed for use in fluorescence image-guided PDT. BDP-8/BDP-9 exhibited high molar absorption coefficients, prominent aggregation-induced emission, and excellent singlet oxygen generation capability upon light irradiation. The corresponding BODIPY nanoparticles (BDP-8/BDP-9 NPs) with bright red emission, considerable phototoxicity, and excellent tumor-targeting ability were simply prepared by encapsulating BDP-8/BDP-9 PSs in a polymeric matrix. More importantly, the results of both in vitro and in vivo experiments demonstrated the considerable potential of BDP-8 NPs for image-guided photodynamic cancer therapy. This study may inspire the development of potential BODIPY-based nanoagents for cancer theranostics.
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