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Abstract
1 Department of Plant Science and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea
2 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
3 Department of Plant Molecular Genetics, Centro Nacional de Biotecnología-CSIC, Madrid 28049, Spain
4 State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
5 National Plant Gene Research Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
6 National Institute of Biological Sciences, Beijing 102206, China
7 Department of Biological Sciences, Seoul National University, Seoul 151-721, Korea
* Corresponding author
8 These authors contributed equally to this work
9 Present address: College of Life Sciences, Capital Normal University, Beijing 100037, China
10 Present address: School of Biological and Chemical Sciences, Queen Mary, University of London, E1 4NS London, UK
SummarySeasonal changes in day length are perceived by plant photoreceptors and transmitted to the circadian clock to modulate developmental responses such as flowering time. Blue-light-sensing cryptochromes, the E3 ubiquitin-ligase COP1, and clock-associated proteins ELF3 and GI regulate this process, although the regulatory link between them is unclear. Here we present data showing that COP1 acts with ELF3 to mediate day length signaling from CRY2 to GI within the photoperiod flowering pathway. We found that COP1 and ELF3 interact in vivo and show that ELF3 allows COP1 to interact with GI in vivo, leading to GI degradation in planta. Accordingly, mutation of COP1 or ELF3 disturbs the pattern of GI cyclic accumulation. We propose a model in which ELF3 acts as a substrate adaptor, enabling COP1 to modulate light input signal to the circadian clock through targeted destabilization of GI.
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