한빛사 논문
Sung Hwan Lee1,2,3,#, Yun Seong Jeong1,#, Sunyoung Lee4, Bo Hwa Sohn1, Ho Kyoung Hwang2, Gi Hong Choi2, Chang Moo Kang2, Jin Sub Choi2, Woo Jung Lee2, Jae-Ho Cheong5, Hee Jin Jang6, Ahmed Kaseb4, Lewis Roberts7, Sun Young Yim8, Yun Shin Chun9, Ju-Seog Lee1,*
1Department of Systems Biology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
3Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea
4Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
5Department of Surgery, Yonsei University Health System Yonsei University College of Medicine, Seoul 03722, Republic of Korea
6Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
7Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55902, USA
8Division of Gastroenterology and Hepatology, Departmentof Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea
9Department of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
*CorrespondenceJu-Seog Lee, Department of Systems Biology, Unit 1058,The University of Texas MD Anderson Cancer Center,1515 Holcombe Blvd., Houston, TX 77030, USA.
#SH Lee and YS Jeong contributed equally to the study.
Abstract
Dear Editor
Hepatocellular carcinoma (HCC) is among the most common cancers worldwide, causing about 600,000 deaths annually [1]. In HCC, stem cell-like characteristics, which drive early recurrence and therapy resistance, are major contributors to poor prognosis [2]. In this current study, we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors (n = 1231) and uncovered two clinically and biologically distinct hepatic stem cell (HS) subtypes, potential biomarkers associated with these subtypes, and a potential new therapeutic intervention for these subtypes.
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